Population Pharmacokinetics of Diazoxide in Children with Hyperinsulinemic Hypoglycemia
نویسندگان
چکیده
منابع مشابه
Diazoxide-responsive hyperinsulinemic hypoglycemia caused by HNF4A gene mutations
OBJECTIVE The phenotype associated with heterozygous HNF4A gene mutations has recently been extended to include diazoxide responsive neonatal hypoglycemia in addition to maturity-onset diabetes of the young (MODY). To date, mutation screening has been limited to patients with a family history consistent with MODY. In this study, we investigated the prevalence of HNF4A mutations in a large cohor...
متن کاملSafety and tolerability of diazoxide in Japanese patients with hyperinsulinemic hypoglycemia.
Diazoxide is a non-diuretic benzothiadiazine derivative, one of a group of substances introduced into clinical practice in the 1950s for the treatment of hypertension. Fajans reported the use of diazoxide for the treatment of insulinoma in 1979. Although patients with hyperinsulinemic hypoglycemia worldwide have been treated with diazoxide for more than 30 years, there are no recent reports abo...
متن کاملPersistent hyperinsulinemic hypoglycemia of infancy.
OBJECTIVE To study the nature and clinical course of persistent hyperinsulinemic hypoglycemia of infancy (PHHI) due to nesidioblastosis. DESIGN Clinical, laboratory and therapeutic evaluation of infants with this disorder and study the outcome. SETTING Hospital born neonates and infants referred from other hospitals. SUBJECTS Thirteen infants from 9 families inclusive of four pairs of sib...
متن کاملHyperinsulinemic Hypoglycemia – The Molecular Mechanisms
Under normal physiological conditions, pancreatic β-cells secrete insulin to maintain fasting blood glucose levels in the range 3.5-5.5 mmol/L. In hyperinsulinemic hypoglycemia (HH), this precise regulation of insulin secretion is perturbed so that insulin continues to be secreted in the presence of hypoglycemia. HH may be due to genetic causes (congenital) or secondary to certain risk factors....
متن کاملBeneficial effect of diazoxide in obese hyperinsulinemic adults.
UNLABELLED Hyperinsulinemia, insulin resistance, and increased adipose tissue are hallmarks of the obesity state in both humans and experimental animals. The role of hyperinsulinemia as a possible preceding event in the development of obesity has been proposed. We previously demonstrated that administration of diazoxide (DZ), an inhibitor of insulin secretion, to obese hyperinsulinemic Zucker r...
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ژورنال
عنوان ژورنال: Hormone Research in Paediatrics
سال: 2017
ISSN: 1663-2818,1663-2826
DOI: 10.1159/000478696